DELAYED HEMOLYTIC TRANSFUSION REACTIONS ( DHTR) AND HYPERHEMOLYSIS SYNDROME IN CHILDREN WITH SICKLE CELL DISEASE (SCD ) : A CASE REPORT: JUBAIL, KINGDOM OF SAUDI ARABIA
نویسندگان
چکیده
Delayed hemolytic transfusion reactions (DHTRs) occur in patients who have received transfusions the past. These may very low antibody titers that are undetectable on pretransfusion testing, so seemingly compatible units of red blood cells (RBCs) transfused. DHTRs a potentially life-threatening complication sickle-cell disease (SCD) treatment. In SCD, appear to be an immune process develop because differences erythrocyte antigens between donors and patients. Aim:DHTR is one serious happens due alloimmunized which lead hyperhaemolysis syndrome , DHTR can managed by steroid Intravenous immunoglobulin ( IVIG ) prevented accurate records with extended matching for certain population. Methodology: The consent patient his family was obtained publish highlight health condition detail follow up case match research results work it under framework reporting. Conclusion: good outcomes,DHTR means records, population high risk developing alloantibodies such as individuals SCD B-thalassemia proper handling administration product notation medical bank well use card known RBC alloantibodies.
منابع مشابه
Delayed hemolytic transfusion reaction/hyperhemolysis syndrome in children with sickle cell disease.
OBJECTIVE Alloimmunization in patients with sickle cell disease (SCD) has a reported incidence of 5% to 36%. One complication of alloimmunization is delayed hemolytic transfusion reaction/hyperhemolysis (DHTR/H) syndrome, which has a reported incidence of 11%. In patients with SCD, clinical findings in DHTR/H syndrome occur approximately 1 week after the red blood cell (RBC) transfusion and inc...
متن کاملDelayed hemolytic transfusion reaction in children with sickle cell disease.
BACKGROUND Transfusion is a cornerstone of the management of sickle cell disease but carries a high risk of hemolytic transfusion reaction, probably because of differences in erythrocyte antigens between blood donors of European descent and patients of African descent. Patients may experience hemolytic transfusion reactions that are delayed by from a few days to two weeks and manifest as acute ...
متن کاملCase reports: delayed hemolytic transfusion reaction in sickle cell disease.
This article reports the details of delayed hemolytic transfusion reactions in four patients with sickle cell disease. These cases demonstrate the characteristics of the reactions, the significant risks involved, and the principles useful in diagnosis and treatment. Patients with sickle cell disease are at particular risk for delayed hemolytic transfusion reactions because they may be transfuse...
متن کاملDelayed Hemolytic Transfusion Reaction in Sickle Cell Disease
Patients with sickle cell disease frequently require red blood cell transfusions . However, transfusions can cause delayed hemolytic transfusion reaction (DHTR), a serious and potentially life-threatening complication of alloimmunization that results in hemolysis of transfused as well as patients’ own red cells . Although we are beginning to understand some of the pathophysiology and risk facto...
متن کاملDelayed hemolytic transfusion reactions.
Delayed hemolytic transfusion reactions continue to occur in spite of the use of all of the currently available techniques of antibody detection. Both low titers of the antibodies and dosage effects appear to contribute to the failure of detection. A rapid anamnestic response can occur with transfusion of the appropriate antigen. The clinical as well as the laboratory presentation of delayed he...
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ژورنال
عنوان ژورنال: International journal of advanced research
سال: 2021
ISSN: ['2707-7802', '2707-7810']
DOI: https://doi.org/10.21474/ijar01/13207